GHK-Cu Protocol
Dosing & Research
Last Updated: April 22, 2026
Dermal remodeling, Hair-growth studies, Wound repair, Copper-dependent regenerative signaling
Evidence Level
Mixed Evidence
Species Studied
Human • Rat • In vitro
Half-Life
Topical Kinetics Undefined
Administration
• Subcutaneous
• Topical
Frequency
Once Daily
How It Works
- Dermal remodeling
- Hair-growth studies
- Wound repair
- Copper-dependent regenerative signaling
Dosing Structure
Dose
1.7–2.0 mg daily
Frequency
Once Daily
Notes
Topical: Apply 0.1–2% concentration cream or serum to target area. Higher concentrations (1–2%) for active repair; lower (0.1–0.5%) for maintenance. Injection: 1–2mg per day via SubQ injection. Reconstitution: 50mg vial mixed with 3ml bacteriostatic water yields approximately 16.67mg/ml (inject 0.06–0.12ml daily for 1–2mg dose). 100mg vial mixed with 3ml bac yields approximately 33.3mg/ml (inject 0.03–0.06ml daily). Cycle: 2 months on, 1 month break. Break: 4-6 weeks.
Example Protocols
Dose: 1.7–2.0 mg daily
Frequency: Once Daily
Duration: 4-8 weeks
Off Period: Not listed
Protocol Notes
•
Topical: Apply 0.1–2% concentration cream or serum to target area.
•
Higher concentrations (1–2%) for active repair; lower (0.1–0.5%) for maintenance.
•
Injection: 1–2mg per day via SubQ injection.
•
Reconstitution: 50mg vial mixed with 3ml bacteriostatic water yields approximately 16.67mg/ml (inject 0.06–0.12ml daily for 1–2mg dose).
•
100mg vial mixed with 3ml bac yields approximately 33.3mg/ml (inject 0.03–0.06ml daily).
•
Cycle: 2 months on, 1 month break.
•
Break: 4-6 weeks.
Research & Studies
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- Curated References
- CuratedPubMedPMID 25484452GHK peptide as a natural modulator of multiple cellular pathways in skin regeneration↗Biomed Res Int · 2018 · Pickart L, Margolina A.mechanismgene expressionskin
- CuratedPubMedPMID 28629895GHK-Cu may prevent oxidative stress in skin↗Cosmetics · 2015 · Pickart L, Vasquez-Soltero JM, Margolina A.antioxidantskinmechanism
- CuratedPubMedPMID 17321614Wound healing promotion by GHK-Cu under the influence of CuSO4↗Wound Repair Regen · 2007 · Leyden JJ, Rawlings AV.wound healinghuman
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