Melanotan II Protocol
Dosing & Research
Last Updated: April 22, 2026
Tanning and melanocortin signaling, Libido research, Appetite suppression studies, Melanogenesis
Evidence Level
Mixed Evidence
Species Studied
Human • Rat • Mouse
Half-Life
~1 Hour
Administration
Subcutaneous
Frequency
Daily for 1 week (loading); 2x weekly (maintenance)
How It Works
- Tanning and melanocortin signaling
- Libido research
- Appetite suppression studies
- Melanogenesis
Dosing Structure
Dose
250 mcg
Frequency
Daily for 1 week (loading); 2x weekly (maintenance)
Notes
Loading (week 1): Start At 50mcg/Day And Titrate Up To 200mcg/Day Based On Tolerance. Adjust Based On Pigment Changes. Maintenance: 50–100mcg 2x Per Week. Metabolic Support: 50mcg Per Day, Expect Some Pigmentation. Cycle: 4–6 Weeks With 4 Week Minimum Break. Do Not Stack With Melanotan I. Do Not Use If At Risk Of Melanoma Or Other Skin Cancer. Inject: Abdomen (preferred), Thigh, Upper Arm. Break: 4 Weeks Minimum.
Example Protocols
Dose: 250 mcg
Frequency: Daily for 1 week (loading); 2x weekly (maintenance)
Duration: 6-8 weeks
Off Period: Not listed
Protocol Notes
•
Loading (week 1): Start at 50mcg/day and titrate up to 200mcg/day based on tolerance.
•
Adjust based on pigment changes.
•
Maintenance: 50–100mcg 2x per week.
•
Metabolic Support: 50mcg per day, expect some pigmentation.
•
Cycle: 4–6 weeks with 4 week minimum break.
•
Do not stack with Melanotan I.
•
Do not use if at risk of melanoma or other skin cancer.
•
Inject: Abdomen (preferred), thigh, upper arm.
•
Break: 4 weeks minimum.
Research & Studies
Loading citations…
- Curated References
- CuratedPubMedPMID 9665198Melanotan II - a clinical study of subcutaneous injections in 30 human subjects↗J Invest Dermatol · 1996 · Dorr RT, Lines R, Levine N, et al.humandosingtanningsafety
- CuratedPubMedPMID 8641826Melanocortin receptor agonist melanotan II causes penile erection↗J Urol · 1998 · Wessells H, Fuciarelli K, Hansen J, et al.humanerectiledosing
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