PT-141 Protocol
Dosing & Research
Last Updated: April 22, 2026
Hypoactive sexual desire studies, Melanocortin receptor pharmacology, Female sexual function, Arousal signaling
Evidence Level
Human Clinical Data Available
Species Studied
Human • Rat • Mouse
Half-Life
~2.7 Hours
Administration
Subcutaneous
Frequency
As Needed
How It Works
- Hypoactive sexual desire studies
- Melanocortin receptor pharmacology
- Female sexual function
- Arousal signaling
Dosing Structure
Dose
200–500 mcg as needed, start at lower end)
Frequency
As Needed
Notes
Dose-sensitive: Start at 0.5mg and titrate up to 2mg based on response. Many individuals find 0.5–1mg sufficient; higher doses increase side-effect risk (nausea, flushing). Taken at least 45 minutes before activity. No specific cycle duration; should only be administered once every 24 hours with a maximum of 8 administrations per month. Expect individual variability on how fast effects are felt. Inject: SubQ abdomen (2 inches from navel) or upper thigh. Minimum 24 hours between doses.
Example Protocols
Dose: 200–500 mcg as needed, start at lower end)
Frequency: As Needed
Duration: As needed; max 8 administrations per month
Off Period: Not listed
Protocol Notes
•
Dose-sensitive: Start at 0.5mg and titrate up to 2mg based on response.
•
Many individuals find 0.5–1mg sufficient; higher doses increase side-effect risk (nausea, flushing).
•
Taken at least 45 minutes before activity.
•
No specific cycle duration; should only be administered once every 24 hours with a maximum of 8 administrations per month.
•
Expect individual variability on how fast effects are felt.
•
Inject: SubQ abdomen (2 inches from navel) or upper thigh.
•
Minimum 24 hours between doses.
Research & Studies
Loading citations…
- Curated References
- CuratedPubMedPMID 30865854Bremelanotide for Female Sexual Dysfunctions in Premenopausal Women (RECONNECT Studies)↗Obstet Gynecol · 2019 · Simon JA, Kingsberg SA, Portman DJ, et al.dosinghumanphase-3HSDD
- CuratedPubMedPMID 14974172Bremelanotide: an overview of preclinical CNS effects on female and male sexual function↗Ann N Y Acad Sci · 2004 · Pfaus JG, Shadiack A, Van Soest T, et al.mechanismhumanmaleerectile
- CuratedPubMedPMID 17852659Melanocortin receptor-4 is required for penile erection in both central and peripheral pathways↗Proc Natl Acad Sci USA · 2002 · Van der Ploeg LH, Martin WJ, Howard AD, et al.mechanismMC4Ranimal
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