Metabolic effects of a GLP-1 analog combined with aerobic training in ovariectomized rats

2027 | Molecular and cellular endocrinology | Journal Article

Matched peptide: Semaglutide | Metabolic | Rat

Menopause is associated with visceral obesity, low-grade chronic inflammation, and increased risk of dyslipidemia, insulin resistance, and type 2 diabetes. Although exercise (EXE) and GLP-1 receptor agonists, such as semaglutide (SEM), have demonstrated beneficial effects on metabolic regulation, their combined impact in menopause...

Investigational Peptides in Orthopaedic Practice: Evidence, Safety, and Patient Counseling for BPC-157, Thymosin Beta-4, and TB-500

2026 | The Journal of the American Academy of Orthopaedic Surgeons | Journal Article

Matched peptide: BPC-157 | Healing & Recovery | Human

Peptide-based products, particularly Body Protection Compound-157 (BPC-157), and thymosin beta-4 (TB-4), and products marketed as TB-500, are increasingly promoted for musculoskeletal recovery despite limited clinical validation. This narrative review evaluated their molecular rationale, direct musculoskeletal evidence, human safety...

12-month weight-loss trajectories and predictors of response to tirzepatide under individualized dosing: A multicenter real-world study

2026 | Obesity pillars | Journal Article

Matched peptide: Tirzepatide | Metabolic

Real-world evidence on 12-month treatment effectiveness and persistence with tirzepatide remains limited, particularly under individualized dosing and self-funded treatment conditions. We evaluated 12-month tirzepatide outcomes in routine clinical practice. This was a multicenter, retrospective, observational real-world study...

Pharmacy students' knowledge and attitudes regarding GLP-1 receptor agonist adverse effects in obesity management: a cross-sectional study

2026 | The Libyan journal of medicine | Journal Article

Matched peptide: Semaglutide | Metabolic

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are important therapeutic options for obesity and type 2 diabetes mellitus. Despite their increasing use, safety concerns remain, and pharmacy students' knowledge of their adverse effects is unclear. This study evaluated pharmacy students' knowledge and attitudes regarding GLP-1 RA...

Human evidence for BPC-157 in orthopaedic and regenerative medicine: a systematic review of efficacy and safety

2026 | Acta orthopaedica Belgica | Journal Article

Matched peptide: BPC-157 | Healing & Recovery | Human

or mzyjp23@nottingham.ac.uk Body Protective Compound-157 (BPC-157) is a synthetic pentadecapeptide popular among athletic populations for musculoskeletal injury recovery, despite lacking regulatory approval for human use and evidence being largely limited to animal models. This PRISMA-compliant systematic review, prospectively...

The pharmacotherapy for pediatric obesity: insights and challenges from adult weight-loss medications

2026 | Journal of diabetes and metabolic disorders | Journal Article

Matched peptide: Retatrutide | Metabolic

Obesity significantly increases the risk of developing other chronic diseases and shortens the life expectancy by 5 to 8 years. Childhood obesity is particularly prominent as 80% of teenagers with obesity have shown it to persist into adulthood. With reference to the development of adult medication, the present review summarises the...

GLP-1 receptor biology and the therapeutic role of incretin-based agonists in metabolic diseases

2026 | European journal of pharmacology | Journal Article

Matched peptide: Retatrutide | Metabolic

Type 2 diabetes (T2DM) and obesity represent a growing global health burden, sharing underlying pathophysiological mechanisms such as impaired insulin signalling and chronic low-grade inflammation. The discovery of the incretin effect opened the way for agonist therapies targeting the glucagon-like peptide-1 receptor (GLP-1R) as...

Tirzepatide alleviates hepatic steatosis and inflammation in MASLD partly through suppression of macrophage Dectin-1/Syk/NF-κB signaling

2026 | European journal of pharmacology | Journal Article

Matched peptide: Tirzepatide | Metabolic

Metabolic stress, hepatic lipid accumulation, and macrophage-associated sterile inflammation are closely involved in the development of metabolic dysfunction-associated steatotic liver disease (MASLD). Tirzepatide improves metabolic outcomes, but its effects on macrophage inflammatory signaling in MASLD remain unclear. This study...

Detection and Excretion Profile of Retatrutide in Human Plasma and Urine by LC-HRMS: Implications for Antidoping Analysis

2026 | Rapid communications in mass spectrometry : RCM | Journal Article

Matched peptide: Retatrutide | Metabolic | Human

Retatrutide (LY3437943) is a novel long-acting triple incretin receptor agonist that targets the glucagon-like peptide-1 receptor (GLP-1R), glucose-dependent insulinotropic polypeptide receptor (GIPR), and glucagon receptor (GCGR). Its pronounced effects on body composition and metabolic health, combined with increasing off-label use...

Efficient Expression of Small Molecule Bioactive Peptides in Bacillus licheniformis

2026 | Applied biochemistry and biotechnology | Journal Article

Matched peptide: BPC-157 | Healing & Recovery

Stable expression of γ-Glutamyltranspeptidase (GGT)-BPC157 and mScarlet-BPC157 in Bacillus licheniformis strain 2709 by chromosomal integration. Fermentation conditions were optimized using single-factor and orthogonal experiments to maximize yield. Under optimal conditions (2% inoculum, 40 g/L soybean peptone, and...

Hunger pain and its reduction; qualitative insight from people with schizophrenia on semaglutide

2026 | International journal of qualitative studies on health and well-being | Journal Article

Matched peptide: Semaglutide | Metabolic

It is often reported that people with schizophrenia experience weight gain and disordered eating, partly due to antipsychotics. As part of the RCT "Home-based Intervention with Semaglutide Treatment of Neuroleptic-Related Prediabetes, HISTORI", the present study investigates experiences of hunger and eating habits in people using...