Efficient Expression of Small Molecule Bioactive Peptides in Bacillus licheniformis

2026 | Applied biochemistry and biotechnology | Journal Article

Matched peptide: BPC-157 | Healing & Recovery

Stable expression of γ-Glutamyltranspeptidase (GGT)-BPC157 and mScarlet-BPC157 in Bacillus licheniformis strain 2709 by chromosomal integration. Fermentation conditions were optimized using single-factor and orthogonal experiments to maximize yield. Under optimal conditions (2% inoculum, 40 g/L soybean peptone, and...

Clinical practice patterns and unmet needs in the use of GLP-1 receptor agonists in sleep medicine: A pan-European survey performed in the European sleep apnoea database network

2026 | Pulmonology | Journal Article

Matched peptide: Tirzepatide | Metabolic

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) and dual GIP/GLP-1 agonists have demonstrated weight loss benefits and reductions in obstructive sleep apnoea (OSA) severity. Following recent regulatory approval of tirzepatide for OSA with obesity, their integration into sleep medicine is accelerating. However, real-world clinical...

Peptides in Regenerative Medicine: A Comprehensive Review of Clinical Applications in Tissue Repair and Chronic Pain Management

2026 | Current pain and headache reports | Journal Article

Matched peptide: BPC-157 | Healing & Recovery

This narrative review summarizes the current evidence on regenerative peptides relevant to chronic pain management, including collagen peptides, body protection compound-157 (BPC-157), thymosin beta-4 (TB-4), thymosin beta-500 (TB-500), glycyl-L-histidyl-L-lysine copper (GHK-Cu), growth hormone-related peptides, and cibinetide...

Comparative effects of semaglutide tirzepatide and retatrutide on renal fibrosis in UUO and aged mice

2026 | iScience | Journal Article

Matched peptide: Retatrutide | Metabolic | Mouse • In Vitro

Chronic kidney disease is a major health burden. Given the therapeutic potential of GLP-1 receptor agonists (semaglutide, tirzepatide, and retatrutide) in diabetic nephropathy, we evaluated their anti-fibrotic and anti-inflammatory effects in non-diabetic renal fibrosis using HK-2 cells and murine UUO and aging models. Integrating in...

Hunger pain and its reduction; qualitative insight from people with schizophrenia on semaglutide

2026 | International journal of qualitative studies on health and well-being | Journal Article

Matched peptide: Semaglutide | Metabolic

It is often reported that people with schizophrenia experience weight gain and disordered eating, partly due to antipsychotics. As part of the RCT "Home-based Intervention with Semaglutide Treatment of Neuroleptic-Related Prediabetes, HISTORI", the present study investigates experiences of hunger and eating habits in people using...

Development and validation of a multiplexed LC-HRMS method for nine GLP-1 receptor agonists and its pharmaceutical application

2026 | Journal of chromatography. A | Journal Article

Matched peptide: Retatrutide | Metabolic

A rapid, sensitive, and selective multiplexed liquid chromatography-high-resolution mass spectrometry (LC-HRMS) method was developed and validated for the identification and quantitation of nine structurally diverse peptide-based glucagon-like peptide-1 receptor agonists (GLP-1 RAs): bofanglutide, ecnoglutide, exenatide, liraglutide,...

Design, synthesis, and stability evaluation of semaglutide-derived lactam-stapled peptide scaffolds for GLP-1R targeting

2026 | Journal of enzyme inhibition and medicinal chemistry | Journal Article

Matched peptide: Semaglutide | Metabolic

Glucagon-like peptide-1 receptor (GLP-1R) ligands including semaglutide play an important role in drug discovery. Herein, a short semaglutide-derived GLP-1R-engaging segment was used as the basis for scaffold construction, and conformational restabilisation was introduced through lactam stapling and bulky aromatic non-natural amino...

Peptide Supplements and Their Therapeutic Applications in Sports Medicine

2026 | The American journal of sports medicine | Journal Article

Matched peptide: BPC-157 | Healing & Recovery | Human

The peptide supplement market has experienced rapid growth due to marketing claims of enhanced performance and accelerated recovery from musculoskeletal injury. These peptides are increasingly popular with patients and athletes and are often perceived as low risk, despite the absence of efficacy or safety data for many emerging...

One receptor, two opposite approaches: efficacy and tolerability of GIPR agonism and antagonism in obesity pharmacotherapy

2026 | Appetite | Journal Article

Matched peptide: Tirzepatide | Metabolic

Glucagon-like peptide-1 receptor (GLP-1R) agonists have transformed obesity pharmacotherapy, producing clinically meaningful weight loss and robust improvements in glycemic control. Yet their efficacy remains constrained by dose-limiting gastrointestinal adverse effects, including nausea and vomiting, that reduce adherence and limit...

Effects of retatrutide on learning and memory in streptozotocin-induced male diabetic rats

2026 | Behavioural brain research | Journal Article

Matched peptide: Retatrutide | Metabolic | Rat

Diabetes mellitus is associated with cognitive impairment and neurodegenerative changes, partly through hyperglycaemia-driven neuroinflammation and disrupted neuronal signalling. Retatrutide, a triple GIP/GLP-1/glucagon receptor agonist, has shown strong metabolic efficacy, but its effects on diabetes-associated cognitive dysfunction...

ATR-FTIR spectroscopy coupled with multivariate analysis for monitoring degradation and secondary structure transitions in therapeutic peptide formulations

2026 | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy | Journal Article

Matched peptide: Semaglutide | Metabolic

Therapeutic peptides represent an important class of biomolecules with great clinical and economic significance, however their structural complexity and susceptibility to degradation pose significant analytical challenges. This study aimed to evaluate the applicability of attenuated total reflectance-Fourier transform infrared...

Enhancing economic modelling in obesity: integrating novel type 2 diabetes progression & obstructive sleep apnea remission - a UK case study

2026 | Journal of medical economics | Journal Article

Matched peptide: Tirzepatide | Metabolic

This study presents an updated health economic model for evaluating the long-term cost-effectiveness of interventions in overweight and obesity, integrating new clinical evidence from the SURMOUNT clinical trial programme and methodological advancements in type-2 diabetes and obstructive sleep apnea (OSA) modelling. An updated...