Comparison of lifestyle, surgery, and semaglutide for weight management in endometrial cancer: a prospective observational study

2026 | Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology | Journal Article

Matched peptide: Semaglutide | Metabolic | Human

To compare sleeve gastrectomy, semaglutide therapy, and the Diet, Exercise, Accompany and Refresh (DEAR) weight management programme for weight control, metabolic improvement, and oncological outcomes in patients with endometrial cancer receiving fertility-sparing treatment. In this prospective observational study, 53 patients...

Retatrutide and the urinary tract infection signal: Is the answer hidden in timing?

2026 | European journal of internal medicine | Letter

Matched peptide: Retatrutide | Metabolic

Medical Treatments for Obesity: What Does the Future Have in Store?

2026 | The Journal of clinical endocrinology and metabolism | Journal Article

Matched peptide: Retatrutide | Metabolic

Obesity is a chronic relapsing disease associated with substantial morbidity, mortality, and health care costs. Contemporary obesity pharmacotherapies extend beyond weight reduction, with evidence for improvements across multiple obesity-related complications, supporting a shift toward phenotype-guided, complication-centric care. A...

Unilateral Adrenalectomy, and the Stable Pentadecapeptide BPC 157 as Therapy in Rats-A Cytoprotection Approach

2026 | Pharmaceuticals (Basel, Switzerland) | Journal Article

Matched peptide: BPC-157 | Healing & Recovery | Rat

Background . This rat study reveals a new point: the considerable impact of unilateral adrenalectomy, severe vascular and multiorgan failure, occlusion/occlusion-like syndrome, and the stable gastric pentadecapeptide BPC 157 therapy. Based on the recent Fourier transform infrared (FTIR) spectroscopy vascular disturbance studies,...

Rapid and harmonized analytical workflow for the determination of peptidic and non-peptidic doping agents in dried and liquid blood matrices

2026 | The Analyst | Journal Article

Matched peptide: BPC-157 | Healing & Recovery

Recently, methods for detecting small peptides in dried blood spots have been published. These procedures typically involve multiple sample preparation steps, resulting in labor-intensive and costly workflows. In the present study, we report a fast, streamlined, and harmonized analytical workflow to detect 54 prohibited peptidic and...

BPC-157 and Its Novel Hybrid Analogs as Inhibitors of Acetylcholinesterase

2026 | International journal of molecular sciences | Journal Article

Matched peptide: BPC-157 | Healing & Recovery

Acetylcholinesterase (AChE) inhibition remains a key therapeutic strategy in the management of neurodegenerative disorders such as Alzheimer's disease. In this study, the inhibitory potential of the gastric pentadecapeptide BPC-157 and two newly designed hybrid analogs, CIARA-1 and CIARA-2, was investigated for the first time. The...

Beyond weight loss: multisystem benefits of obesity medications

2026 | The lancet. Diabetes & endocrinology | Journal Article

Matched peptide: Retatrutide | Metabolic

Obesity is increasingly managed with medications as disease-modifying therapies, reflecting its role as a gateway disease driving metabolic, cardiovascular, reproductive, neuropsychiatric, and mechanical conditions. This Review synthesises evidence from randomised controlled trials and high-quality meta-analyses on approved and...

Enhancing economic modelling in obesity: integrating novel type 2 diabetes progression & obstructive sleep apnea remission - a UK case study

2026 | Journal of medical economics | Journal Article

Matched peptide: Tirzepatide | Metabolic

This study presents an updated health economic model for evaluating the long-term cost-effectiveness of interventions in overweight and obesity, integrating new clinical evidence from the SURMOUNT clinical trial programme and methodological advancements in type-2 diabetes and obstructive sleep apnea (OSA) modelling. An updated...

Cost-effectiveness of tirzepatide versus semaglutide for patients with obesity or overweight in the US: evidence from the SURMOUNT-5 head-to-head phase-3 trial

2026 | Journal of medical economics | Journal Article

Matched peptide: Semaglutide | Metabolic | Human

This study evaluated the cost-effectiveness (from the United States [US] societal perspective) of tirzepatide at its maximum-tolerated-dose (MTD) compared to semaglutide (MTD), both administered adjunct to a reduced-calorie diet and increased physical activity. The analysis focused on individuals with obesity (body mass index...

GLP-1 receptor agonists in stroke prevention: a narrative review on emerging therapeutic frontiers

2026 | Annals of medicine | Journal Article

Matched peptide: Semaglutide | Metabolic

To evaluate the current evidence supporting the cerebrovascular protective effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) in individuals with type 2 diabetes mellitus (T2DM), and to outline their mechanisms of action in stroke prevention. A narrative review was conducted by synthesising data from cardiovascular...

Annual pharmacy cost per patient achieving composite treatment endpoints: a cost to target analysis of tirzepatide versus subcutaneous semaglutide 1 mg in patients with type 2 diabetes in the UK

2026 | Journal of medical economics | Journal Article

Matched peptide: Tirzepatide | Metabolic | Human

Tirzepatide is a treatment for type 2 diabetes associated with improvements in glycemic control and weight loss, and a low risk of hypoglycemia when not used in combination with insulin or insulin secretagogues. A cost to target analysis of tirzepatide 5, 10 and 15 mg versus subcutaneous semaglutide 1 mg in the UK...