Melanotan I Protocol
Dosing & Research
Last Updated: April 22, 2026
Photoprotection research, Melanogenesis studies, EPP-related therapy, UV-resistance models
Evidence Level
Human Clinical Data Available
Species Studied
Human • Mouse
Half-Life
~30 Minutes
Administration
Subcutaneous
Frequency
Daily for 1 week (loading); 2x weekly (maintenance)
How It Works
- Photoprotection research
- Melanogenesis studies
- EPP-related therapy
- UV-resistance models
Dosing Structure
Dose
250 mcg
Frequency
Daily for 1 week (loading); 2x weekly (maintenance)
Notes
Loading (week 1): Start at 50mcg/day and titrate up to 200mcg/day based on tolerance. Adjust based on pigment changes. Maintenance dose: 100mcg 2x per week. May reduce if desired. Cycle: 4–6 weeks; take a break before resuming. Do not stack with Melanotan II. Inject: Abdomen, thigh, upper arm (rotate). Morning and evening 6-8 hours apart.
Example Protocols
Dose: 250 mcg
Frequency: Daily for 1 week (loading); 2x weekly (maintenance)
Duration: 6-8 weeks
Off Period: Not listed
Protocol Notes
•
Loading (week 1): Start at 50mcg/day and titrate up to 200mcg/day based on tolerance.
•
Adjust based on pigment changes.
•
Maintenance dose: 100mcg 2x per week.
•
May reduce if desired.
•
Cycle: 4–6 weeks; take a break before resuming.
•
Do not stack with Melanotan II.
•
Inject: Abdomen, thigh, upper arm (rotate).
•
Morning and evening 6-8 hours apart.
Research & Studies
Loading citations…
- Curated References
- CuratedPubMedPMID 26362826Afamelanotide for Erythropoietic Protoporphyria↗N Engl J Med · 2015 · Langendonk JG, Balwani M, Anderson KE, et al.phase-3EPPhumandosing
- CuratedPubMedPMID 20375602Systemic afamelanotide in EPP patients increases pain-free light exposure↗Acta Derm Venereol · 2009 · Harms J, Lautenschlager S, Minder CE, Minder EI.humanphotoprotectiondosing
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