BPC-157 Protocol
Dosing & Research
Last Updated: April 22, 2026
Gastrointestinal repair models, Tendon/ligament healing, Angiogenesis and nitric-oxide signaling, Inflammation modulation
Evidence Level
Animal Models Primary
Species Studied
Rat • Mouse • In vitro
Half-Life
4-6 hours
Administration
• Subcutaneous
• Oral
Frequency
Once Daily Or Split Into Twice Daily (morning And Evening)
How It Works
- Gastrointestinal repair models
- Tendon/ligament healing
- Angiogenesis and nitric-oxide signaling
- Inflammation modulation
Dosing Structure
Dose
250–500 mcg daily
Frequency
Once Daily Or Split Into Twice Daily (morning And Evening)
Notes
Injection: 200–600mcg daily. Lower end (200–300mcg) may be used for localized targeting near an injury site; higher doses (400–600mcg) for systemic support. Some users prefer splitting dose into twice daily, morning and evening. Oral: 500–1000mcg daily. Benefits are systemic but some recommend injecting near injury for additional benefit. Inject: Belly, thigh, arm. Empty stomach preferred. Strict cycling data is limited. Reassess every 8 weeks.
Example Protocols
Dose: 250–500 mcg daily
Frequency: Once Daily Or Split Into Twice Daily (morning And Evening)
Duration: 4-12 weeks
Off Period: Not listed
Protocol Notes
•
Injection: 200–600mcg daily.
•
Lower end (200–300mcg) may be used for localized targeting near an injury site; higher doses (400–600mcg) for systemic support.
•
Some users prefer splitting dose into twice daily, morning and evening.
•
Oral: 500–1000mcg daily.
•
Benefits are systemic but some recommend injecting near injury for additional benefit.
•
Inject: Belly, thigh, arm.
•
Empty stomach preferred.
•
Strict cycling data is limited.
•
Reassess every 8 weeks.
Research & Studies
Loading citations…
- Curated References
- CuratedPubMedPMID 24380553BPC 157 accelerates healing of transected rat Achilles tendon and medial collateral ligament↗J Orthop Surg Res · 2010 · Pevec D, Novinscak T, Brcic L, et al.dosinghealinganimal
- CuratedPubMedPMID 21220747Stable gastric pentadecapeptide BPC 157 heals cysteamine-colitis and rat duodenal ulcers↗World J Gastroenterol · 2011 · Sikiric P, Seiwerth S, Rucman R, et al.mechanismGIanimal
- CuratedPubMedPMID 20171542BPC 157: a review of central nervous system effects↗Curr Neuropharmacol · 2010 · Sikiric P, Seiwerth S, Rucman R, et al.mechanismangiogenesis
- CuratedPubMedPMID 28854488Stable gastric pentadecapeptide BPC 157: novel therapy of a myocardial infarction failure in rat↗J Physiol Pharmacol · 2017 · Sikiric P, et al.cardiovascularanimal
- CuratedPubMedPMID 38168447Stable gastric pentadecapeptide BPC 157 heals rectal lesions in rats↗Biomedicines · 2023 · Sikiric P, et al.GIanimaldosing
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