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Growth Hormone Secretagogue

Ipamorelin Protocol

Dosing & Research

Last Updated: September 4, 2026

Chemical Identity
Amino Acid Sequence
Aib-His-D-2-Nal-D-Phe-Lys-NH2
Molecular Formula
C38H49N9O5
Molecular Weight
711.86 g/mol
CAS Number
170851-70-4

Selective GH release research, Sleep/recovery studies, IGF-1 modulation, Combination peptide protocols

Evidence Level
Mixed Evidence
Species Studied
Human • Rat
Half-Life
~2 Hours
Administration
Subcutaneous
Frequency
1-3x daily, fasted (before bed preferred)

How It Works

  • Selective GH release research
  • Sleep/recovery studies
  • IGF-1 modulation
  • Combination peptide protocols

Dosing Structure

Dose
200–300 mcg
Frequency
1-3x daily, fasted (before bed preferred)
Notes
1x Daily: 100–300mcg taken directly before bed, fasted. If fasting before bed isn't possible (2-3 hours after meal), consider taking in the morning. 2x Daily: 100–200mcg before bed and first thing in the morning, fasted. 3x Daily: 100mcg in the morning (fasted), before workout, and before bed (fasted). Inject: Belly, thigh, upper arm. Break: 1-2 months.

Example Protocols

Dose: 200–300 mcg
Frequency: 1-3x daily, fasted (before bed preferred)
Duration: 6-12 weeks
Off Period: Not listed
Calculate dosing →

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Protocol Notes

•
1x Daily: 100–300mcg taken directly before bed, fasted.
•
If fasting before bed isn't possible (2-3 hours after meal), consider taking in the morning.
•
2x Daily: 100–200mcg before bed and first thing in the morning, fasted.
•
3x Daily: 100mcg in the morning (fasted), before workout, and before bed (fasted).
•
Inject: Belly, thigh, upper arm.
•
Break: 1-2 months.

What Is Ipamorelin?

Ipamorelin is a selective growth hormone releasing peptide (GHRP) that triggers GH pulses from the pituitary gland with minimal effect on cortisol or prolactin - a key advantage over older GHRPs. It is studied as a model compound for GH deficiency research, recovery enhancement, and body composition improvement without the off-target hormonal activity seen with GHRP-2 or GHRP-6.

Research Observations - Not Medical Claims
  • ▸Human dose-response study: 200 mcg intravenous ipamorelin produced a mean peak GH of ~20 ng/mL within 30 minutes in healthy adults; cortisol and prolactin were not significantly elevated (PMID: 9849822).
  • ▸Compared to GHRP-6, ipamorelin produced equivalent GH release at similar doses with no significant cortisol stimulation - making it more selective (Raun et al., 1998).
  • ▸Rat chronic administration study: 12-week subcutaneous ipamorelin in old rats increased IGF-1 levels and lean body mass vs. saline controls.
  • ▸Bone density: Ipamorelin administration in ovariectomized rats increased cortical and cancellous bone mineral density - proposed mechanism involves IGF-1 upregulation.
  • ▸No large-scale human clinical trials for anti-aging or body composition outcomes have been published.

Evidence Summary

Mixed EvidenceResearch Only
Evidence StrengthPreliminary
PreliminaryModerateStrong
Curated Citations2
Largest Study (n)32
Most Recent Study2022
Species Studied
HumanRat

Commonly Researched With

BPC-157
BPC-157 handles local tissue repair while Ipamorelin drives systemic GH release - commonly studied together for recovery optimization.
TB-500
TB-500 cell repair activity pairs with Ipamorelin's anabolic GH stimulus for comprehensive tissue recovery.

Research & Studies

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