Ipamorelin Protocol
Dosing & Research
Last Updated: April 22, 2026
Selective GH release research, Sleep/recovery studies, IGF-1 modulation, Combination peptide protocols
Evidence Level
Mixed Evidence
Species Studied
Human • Rat
Half-Life
~2 Hours
Administration
Subcutaneous
Frequency
1-3x daily, fasted (before bed preferred)
How It Works
- Selective GH release research
- Sleep/recovery studies
- IGF-1 modulation
- Combination peptide protocols
Dosing Structure
Dose
200–300 mcg
Frequency
1-3x daily, fasted (before bed preferred)
Notes
1x Daily: 100–300mcg taken directly before bed, fasted. If fasting before bed isn't possible (2-3 hours after meal), consider taking in the morning. 2x Daily: 100–200mcg before bed and first thing in the morning, fasted. 3x Daily: 100mcg in the morning (fasted), before workout, and before bed (fasted). Inject: Belly, thigh, upper arm. Break: 1-2 months.
Example Protocols
Dose: 200–300 mcg
Frequency: 1-3x daily, fasted (before bed preferred)
Duration: 6-12 weeks
Off Period: Not listed
Protocol Notes
•
1x Daily: 100–300mcg taken directly before bed, fasted.
•
If fasting before bed isn't possible (2-3 hours after meal), consider taking in the morning.
•
2x Daily: 100–200mcg before bed and first thing in the morning, fasted.
•
3x Daily: 100mcg in the morning (fasted), before workout, and before bed (fasted).
•
Inject: Belly, thigh, upper arm.
•
Break: 1-2 months.
Research & Studies
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- Curated References
- CuratedPubMedPMID 9849822Ipamorelin, the first selective growth hormone secretagogue↗Eur J Endocrinol · 1998 · Raun K, Hansen BS, Johansen NL, et al.dosingmechanismhumanselectivity
- CuratedPubMedPMID 10401584Ipamorelin stimulates body weight gain in lean and obese Zucker rats↗Eur J Endocrinol · 1999 · Hansen BS, Raun K, Nielsen KK, et al.dosinganimalbody composition
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