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Longevity & Mitochondrial

Epithalon Protocol

Dosing & Research

Last Updated: September 4, 2026

Chemical Identity
Amino Acid Sequence
Ala-Glu-Asp-Gly
Molecular Formula
C14H22N4O9
Molecular Weight
390.35 g/mol
CAS Number
307297-39-8

Telomerase and cellular aging studies, Circadian regulation, Oxidative-stress resilience, Geroprotection research

Evidence Level
In Vitro / Preclinical
Species Studied
Human • Rat • Mouse • In vitro
Half-Life
~30 Minutes
Administration
Subcutaneous
Frequency
Daily For 10 Days, Or Every 3 Days For 17 Days

How It Works

  • Telomerase and cellular aging studies
  • Circadian regulation
  • Oxidative-stress resilience
  • Geroprotection research

Dosing Structure

Dose
2 mg nightly
Frequency
Daily For 10 Days, Or Every 3 Days For 17 Days
Notes
Russian Protocol: 10mg per day for 10 days. 4-6 months break recommended. Ukrainian Protocol: 10mg every 3 days for 17 days. 4-6 months break recommended. Anela Protocol: 1mg per day for 10 days on, 20 days off. This 30-day cycle is reportedly repeatable. Typically administered as defined courses (10–20 days) repeated 1–2x per year, rather than continuous daily dosing. Based on Khavinson Institute and associated Russian clinical research. Inject: Abdomen, thigh, or upper arm. Morning preferred.

Example Protocols

Dose: 2 mg nightly
Frequency: Daily For 10 Days, Or Every 3 Days For 17 Days
Duration: 20 Days (repeat Cycles)
Off Period: Not listed
Calculate dosing →

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Protocol Notes

•
Russian Protocol: 10mg per day for 10 days.
•
4-6 months break recommended.
•
Ukrainian Protocol: 10mg every 3 days for 17 days.
•
4-6 months break recommended.
•
Anela Protocol: 1mg per day for 10 days on, 20 days off.
•
This 30-day cycle is reportedly repeatable.
•
Typically administered as defined courses (10–20 days) repeated 1–2x per year, rather than continuous daily dosing.
•
Based on Khavinson Institute and associated Russian clinical research.
•
Inject: Abdomen, thigh, or upper arm.
•
Morning preferred.

What Is Epithalon?

Epithalon (also spelled Epitalon) is a synthetic tetrapeptide - four amino acids (Ala-Glu-Asp-Gly) - derived from the pineal gland extract Epithalamin. It is studied primarily for its reported ability to elongate telomeres and stimulate telomerase, the enzyme that rebuilds the protective caps on chromosomes associated with cellular aging. Most research originates from Russian scientists led by Dr. Vladimir Khavinson.

Research Observations - Not Medical Claims
  • ▸Telomere elongation in human somatic cells: Epithalon restored telomerase activity and elongated telomeres in human fetal fibroblasts that had reached senescence in vitro (PMID: 12374906; Khavinson et al., 2002).
  • ▸Lifespan extension: In Drosophila melanogaster (fruit fly), Epithalon extended median lifespan by 11–16% and maximum lifespan by 13% vs. controls (PMID: 12802523).
  • ▸Melatonin regulation: Epithalon stimulated melatonin synthesis in elderly subjects in a small Russian clinical study (Anisimov et al., 2001) - one of very few human data points.
  • ▸Cancer models: Administration in mice with spontaneous mammary tumors reduced tumor incidence and extended time-to-tumor development.
  • ▸Oxidative stress: Reduced lipid peroxidation markers in aging rats; proposed mechanism involves superoxide dismutase upregulation.
  • ▸Note: Most research is from a single research group in Russia; independent replication is limited.

Evidence Summary

In Vitro / PreclinicalResearch Only
Evidence StrengthPreliminary
PreliminaryModerateStrong
Curated Citations3
Largest Study (n)14
Most Recent Study2022
Species Studied
HumanRatMouseIn vitro

Commonly Researched With

NAD+
Both target cellular aging mechanisms - NAD+ restores mitochondrial energy metabolism while Epithalon targets telomere maintenance; combined in longevity research protocols.
GHK-Cu
GHK-Cu gene expression data shows overlap with DNA repair and cellular remodeling pathways complementary to Epithalon's proposed epigenetic effects.

Research & Studies

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