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Nootropic & Neuro

Selank Protocol

Dosing & Research

Last Updated: September 4, 2026

Chemical Identity
Amino Acid Sequence
Thr-Lys-Pro-Arg-Pro-Gly-Pro
Molecular Formula
C33H57N11O9
Molecular Weight
751.90 g/mol
CAS Number
129954-34-3

Anxiolytic and stress research, Immune-neuro interface studies, Cognition/focus models, Nasal peptide delivery

Evidence Level
Human Clinical Data Available
Species Studied
Human • Rat • Mouse
Half-Life
Minutes (plasma); extended CNS activity
Administration
• Intranasal • Subcutaneous
Frequency
Daily or 3-5x weekly

How It Works

  • Anxiolytic and stress research
  • Immune-neuro interface studies
  • Cognition/focus models
  • Nasal peptide delivery

Dosing Structure

Dose
200–500 mcg
Frequency
Daily or 3-5x weekly
Notes
Daily SubQ: 100-300mcg. 3x-5x per week SubQ: 200-500mcg (some protocols call for a max of 1mg per day). Intranasal: 750mcg-1mg. Cycle Durations: Daily: 1 month on, 1 month off. 3-5x per week: 2 months on, 2 months off. Inject: Abdomen, thigh, or upper arm. Morning for cognitive, evening for anxiety. Break: 1-2 weeks (optional).

Example Protocols

Dose: 200–500 mcg
Frequency: Daily or 3-5x weekly
Duration: 8 Weeks
Off Period: Not listed
Calculate dosing →

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Protocol Notes

•
Daily SubQ: 100-300mcg.
•
3x-5x per week SubQ: 200-500mcg (some protocols call for a max of 1mg per day).
•
Intranasal: 750mcg-1mg.
•
Cycle Durations: Daily: 1 month on, 1 month off.
•
3-5x per week: 2 months on, 2 months off.
•
Inject: Abdomen, thigh, or upper arm.
•
Morning for cognitive, evening for anxiety.
•
Break: 1-2 weeks (optional).

What Is Selank?

Selank is a synthetic heptapeptide analogue of tuftsin (a naturally occurring immunomodulatory peptide) developed by the Institute of Molecular Genetics of the Russian Academy of Sciences. It is registered in Russia and Ukraine as an anxiolytic - a drug that reduces anxiety without the sedation or dependence risks of benzodiazepines. It modulates GABA, serotonin, and dopamine systems and has been studied for generalized anxiety disorder, cognitive enhancement, and immune modulation.

Research Observations - Not Medical Claims
  • ▸Anxiolytic activity: Multiple Russian RCTs (n=60–80 per study) showed intranasal Selank (250–500 mcg 2–3×/day) equivalent to fenazepam (a benzodiazepine) for anxiety reduction in GAD patients without sedation or cognitive impairment (PMID: 19718432).
  • ▸BDNF upregulation: Selank increases brain-derived neurotrophic factor (BDNF) - proposed mechanism for cognitive enhancement and neuroprotection effects observed in animal models.
  • ▸Serotonin/tryptophan: Selank modulates tryptophan metabolism and serotonin turnover - an alternative to monoamine-targeting anxiolytics.
  • ▸Immune modulation: Selank increases IL-6 production and regulates T-helper cell balance - the tuftsin backbone provides immunostimulatory properties alongside anxiolytic effects.
  • ▸No tolerance or withdrawal: Unlike benzodiazepines, repeated Selank administration in Russian trials showed no tolerance development or withdrawal syndrome on cessation - a key clinical advantage studied.

Evidence Summary

Human Clinical Data AvailableRegistered drug in Russia and Ukraine - Research Chemical in US, EU, and most Western countries
Evidence StrengthModerate
PreliminaryModerateStrong
Curated Citations2
Largest Study (n)80
Most Recent Study2023
Species Studied
HumanRatMouse

Commonly Researched With

Semax
The classic Russian nootropic stack - Selank for anxiety reduction + Semax for cognitive enhancement; often studied or used together.
DSIP
DSIP's sleep-promoting activity complements Selank's anxiolytic properties in stress and sleep quality research.
BPC-157
BPC-157's neuroprotective and anti-inflammatory CNS effects are studied alongside Selank in neurological research.

Research & Studies

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