MOTS-C Protocol
Dosing & Research
Last Updated: April 22, 2026
Exercise mimetic research, Insulin sensitivity, Mitochondrial stress adaptation, Healthy aging studies
Evidence Level
Animal Models Primary
Species Studied
Human • Mouse • Rat
Half-Life
~4 Hours (estimated)
Administration
Subcutaneous
Frequency
3x weekly (weeks 1-4 initial); 1x weekly (weeks 5-8 maintenance)
How It Works
- Exercise mimetic research
- Insulin sensitivity
- Mitochondrial stress adaptation
- Healthy aging studies
Dosing Structure
Dose
1 mg 3-5x weekly
Frequency
3x weekly (weeks 1-4 initial); 1x weekly (weeks 5-8 maintenance)
Notes
Initial Stage (Weeks 1-4): 5mg taken 3 times per week. Maintenance Stage (Weeks 5-8): 5mg taken 1 time per week. Cycle: 8 weeks with 4-week break. For more aggressive protocols, consider increasing doses to 10mg. Do not stack with AICAR. Inject: Abdomen, thigh, upper arm (rotate). Morning before exercise. Break: 2-4 weeks between continuous cycles.
Example Protocols
Dose: 1 mg 3-5x weekly
Frequency: 3x weekly (weeks 1-4 initial); 1x weekly (weeks 5-8 maintenance)
Duration: 6-8 weeks
Off Period: Not listed
Protocol Notes
•
Initial Stage (Weeks 1-4): 5mg taken 3 times per week.
•
Maintenance Stage (Weeks 5-8): 5mg taken 1 time per week.
•
Cycle: 8 weeks with 4-week break.
•
For more aggressive protocols, consider increasing doses to 10mg.
•
Do not stack with AICAR.
•
Inject: Abdomen, thigh, upper arm (rotate).
•
Morning before exercise.
•
Break: 2-4 weeks between continuous cycles.
Research & Studies
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- Curated References
- CuratedPubMedPMID 25735772The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance↗Cell Metab · 2015 · Lee C, Zeng J, Drew BG, et al.mechanismmetabolicanimalinsulin
- CuratedPubMedPMID 31004536MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline↗Nat Commun · 2021 · Reynolds JC, Lai RW, Woodhead JST, et al.exerciseaginganimalmechanism
- CuratedPubMedPMID 31485084MOTS-c targets mitochondria and the nucleus to regulate AMPK-associated metabolic response↗Elife · 2019 · Kim SJ, Mehta HH, Wan J, et al.mechanismAMPKnuclearin vitro
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