AICAR Protocol
Dosing & Research
Last Updated: September 4, 2026
Also known as: AICA Ribonucleotide, Acadesine
AMPK activation, Exercise mimetic research, Metabolic adaptation, Endurance and fat oxidation studies
Half-Life
Not Well Characterized
Administration
Subcutaneous
Frequency
Once Daily, 30 Minutes Before Workout
How It Works
- AMPK activation
- Exercise mimetic research
- Metabolic adaptation
- Endurance and fat oxidation studies
Dosing Structure
Dose
1-3mg/day
Frequency
Once Daily, 30 Minutes Before Workout
Notes
Conservative: 1-3mg per day taken 30 minutes before workout. Aggressive: 25mg per day. Dosing protocols vary greatly and range from 1-25mg per day. Experiment to find appropriate dose. Do not stack with MOTS-C. Be cautious regarding kidney issues. Cycle for 14 days, taking long breaks between cycles.
Example Protocols
Dose: 1-3mg/day
Frequency: Once Daily, 30 Minutes Before Workout
Duration: 14 days; long breaks between cycles
Off Period: Not listed
Find Research Grade AICAR
Recommended vendors for sourcing research-grade material. PeptaBase does not sell peptides directly.
Vendor One Research Labs
COA VerifiedThird-party COA-verified research peptides with published batch testing.
Source Coming SoonVendor Two Sciences
Purity TestedUS-based research compound supplier with independent purity testing.
Source Coming SoonVendor Three Peptide Co.
Bulk research peptide sourcing with batch-level documentation.
Source Coming SoonProtocol Notes
•
Conservative: 1-3mg per day taken 30 minutes before workout.
•
Aggressive: 25mg per day.
•
Dosing protocols vary greatly and range from 1-25mg per day.
•
Experiment to find appropriate dose.
•
Do not stack with MOTS-C.
•
Be cautious regarding kidney issues.
•
Cycle for 14 days, taking long breaks between cycles.
Research & Studies
Loading citations…
Research Feedback
0 approved
For research discussion only. Community feedback is moderated and shown here as aggregated insights after approval.
Be the first to submit research feedback for this peptide.
Approved submissions will appear here as aggregated insights.