AICAR Protocol
Dosing & Research
Last Updated: April 22, 2026
Also known as: AICA Ribonucleotide, Acadesine
AMPK activation, Exercise mimetic research, Metabolic adaptation, Endurance and fat oxidation studies
Half-Life
Not Well Characterized
Administration
Subcutaneous
Frequency
Once Daily, 30 Minutes Before Workout
How It Works
- AMPK activation
- Exercise mimetic research
- Metabolic adaptation
- Endurance and fat oxidation studies
Dosing Structure
Dose
1-3mg/day
Frequency
Once Daily, 30 Minutes Before Workout
Notes
Conservative: 1-3mg per day taken 30 minutes before workout. Aggressive: 25mg per day. Dosing protocols vary greatly and range from 1-25mg per day. Experiment to find appropriate dose. Do not stack with MOTS-C. Be cautious regarding kidney issues. Cycle for 14 days, taking long breaks between cycles.
Example Protocols
Dose: 1-3mg/day
Frequency: Once Daily, 30 Minutes Before Workout
Duration: 14 days; long breaks between cycles
Off Period: Not listed
Protocol Notes
•
Conservative: 1-3mg per day taken 30 minutes before workout.
•
Aggressive: 25mg per day.
•
Dosing protocols vary greatly and range from 1-25mg per day.
•
Experiment to find appropriate dose.
•
Do not stack with MOTS-C.
•
Be cautious regarding kidney issues.
•
Cycle for 14 days, taking long breaks between cycles.
Research & Studies
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