SS-31 Protocol
Dosing & Research
Last Updated: September 4, 2026
Also known as: Elamipretide
Chemical Identity
- Amino Acid Sequence
- D-Arg-Dmt-Lys-Phe-NH2
- Molecular Formula
- C32H49N9O5
- Molecular Weight
- 639.80 g/mol
- CAS Number
- 736992-21-5
Mitochondrial membrane stabilization, Ischemia/reperfusion studies, Muscle fatigue research, Age-related organ dysfunction
Half-Life
~4 Hours
Administration
Subcutaneous
Frequency
5x Weekly
How It Works
- Mitochondrial membrane stabilization
- Ischemia/reperfusion studies
- Muscle fatigue research
- Age-related organ dysfunction
Dosing Structure
Dose
0.5–1 mg
Frequency
5x Weekly
Notes
MOTS-C/NAD+ Prep: 5mg 5x per week for 2 weeks, then start MOTS-C or NAD+ cycle. Consider a lower dose of SS-31 on off days to keep mitochondria healthy. Low Dose Maintenance: 500mcg 5x per week. SS-31 dosing protocols vary greatly depending on source. Clinical trial doses were up to 40mg per day for 24 weeks with no indication of desensitization; however, recommend greater caution and avoid exceeding 12 weeks without a 4-8 week break. Inject: Abdomen, thigh (SubQ). Morning for general use; pre-workout for performance.
Example Protocols
Dose: 0.5–1 mg
Frequency: 5x Weekly
Duration: 6-8 weeks
Off Period: Not listed
Find Research Grade SS-31
Recommended vendors for sourcing research-grade material. PeptaBase does not sell peptides directly.
Vendor One Research Labs
COA VerifiedThird-party COA-verified research peptides with published batch testing.
Source Coming SoonVendor Two Sciences
Purity TestedUS-based research compound supplier with independent purity testing.
Source Coming SoonVendor Three Peptide Co.
Bulk research peptide sourcing with batch-level documentation.
Source Coming SoonProtocol Notes
•
MOTS-C/NAD+ Prep: 5mg 5x per week for 2 weeks, then start MOTS-C or NAD+ cycle.
•
Consider a lower dose of SS-31 on off days to keep mitochondria healthy.
•
Low Dose Maintenance: 500mcg 5x per week.
•
SS-31 dosing protocols vary greatly depending on source.
•
Clinical trial doses were up to 40mg per day for 24 weeks with no indication of desensitization; however, recommend greater caution and avoid exceeding 12 weeks without a 4-8 week break.
•
Inject: Abdomen, thigh (SubQ).
•
Morning for general use; pre-workout for performance.
Research & Studies
Loading citations…
Research Feedback
0 approved
For research discussion only. Community feedback is moderated and shown here as aggregated insights after approval.
Be the first to submit research feedback for this peptide.
Approved submissions will appear here as aggregated insights.