SS-31 Protocol
Dosing & Research
Last Updated: April 22, 2026
Mitochondrial membrane stabilization, Ischemia/reperfusion studies, Muscle fatigue research, Age-related organ dysfunction
Half-Life
~4 Hours
Administration
Subcutaneous
Frequency
5x Weekly
How It Works
- Mitochondrial membrane stabilization
- Ischemia/reperfusion studies
- Muscle fatigue research
- Age-related organ dysfunction
Dosing Structure
Dose
0.5–1 mg
Frequency
5x Weekly
Notes
MOTS-C/NAD+ Prep: 5mg 5x per week for 2 weeks, then start MOTS-C or NAD+ cycle. Consider a lower dose of SS-31 on off days to keep mitochondria healthy. Low Dose Maintenance: 500mcg 5x per week. SS-31 dosing protocols vary greatly depending on source. Clinical trial doses were up to 40mg per day for 24 weeks with no indication of desensitization; however, recommend greater caution and avoid exceeding 12 weeks without a 4-8 week break. Inject: Abdomen, thigh (SubQ). Morning for general use; pre-workout for performance.
Example Protocols
Dose: 0.5–1 mg
Frequency: 5x Weekly
Duration: 6-8 weeks
Off Period: Not listed
Protocol Notes
•
MOTS-C/NAD+ Prep: 5mg 5x per week for 2 weeks, then start MOTS-C or NAD+ cycle.
•
Consider a lower dose of SS-31 on off days to keep mitochondria healthy.
•
Low Dose Maintenance: 500mcg 5x per week.
•
SS-31 dosing protocols vary greatly depending on source.
•
Clinical trial doses were up to 40mg per day for 24 weeks with no indication of desensitization; however, recommend greater caution and avoid exceeding 12 weeks without a 4-8 week break.
•
Inject: Abdomen, thigh (SubQ).
•
Morning for general use; pre-workout for performance.
Research & Studies
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