SHLP6 Protocol

Dosing & Research

Last Updated: September 4, 2026

Also known as: Small Humanin-Like Peptide 6

Chemical Identity

Amino Acid Sequence: MLDQDIPMVQPLLKVRLFND

Mitochondrial-derived peptide signaling research, Apoptosis-regulation studies, Aging and cellular stress-response models

Evidence Level

Preclinical Only -- Limited Data

Species Studied

In vitro

Half-Life

Not Well Characterized In Vivo

Administration

Not established (preclinical research use)

Frequency

Per study protocol; no established human schedule

How It Works

20-amino-acid peptide encoded within the mitochondrial 16S rRNA (MT-RNR2) region, part of the small humanin-like peptide (SHLP1-6) family. Unlike the cytoprotective profile reported for SHLP2, preclinical studies describe SHLP6 as pro-apoptotic in some cell models, and it is studied for potential relevance to cancer-cell biology and age-related mitochondrial signaling.
Mitochondrial-derived peptide signaling research
Apoptosis-regulation studies
Aging and cellular stress-response models

Dosing Structure

Dose

Preclinical research only

Frequency

Per study protocol; no established human schedule

Notes

Substantially less characterized than SHLP2 or Humanin; most available data comes from the original 2016 mitochondrial-derived peptide family characterization. Entirely preclinical; no human dosing or safety data established. Research and laboratory reference only.

Example Protocols

Dose: Preclinical research only

Frequency: Per study protocol; no established human schedule

Duration: Not Established In Humans

Off Period: Not listed

Calculate dosing →

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Third-party COA-verified research peptides with published batch testing.

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Protocol Notes

•

Substantially less characterized than SHLP2 or Humanin; most available data comes from the original 2016 mitochondrial-derived peptide family characterization.

•

Entirely preclinical; no human dosing or safety data established.

•

Research and laboratory reference only.

What Is SHLP6?

SHLP6 (Small Humanin-Like Peptide 6) is a 20-amino-acid peptide encoded within the mitochondrial 16S rRNA gene, part of the same mitochondrial-derived peptide family as SHLP2 and Humanin. Unlike SHLP2's cytoprotective profile, early research describes SHLP6 as pro-apoptotic in some cell models. It is substantially less characterized than its family members and is an entirely preclinical research compound.

Research Observations - Not Medical Claims

▸Family characterization (Aging, 2016; PMID: 27070352): SHLP6 was identified as one of six small humanin-like peptides (SHLP1-6, ranging 20-38 amino acids) encoded in the mitochondrial 16S rRNA region.
▸Divergent activity: In contrast to the cytoprotective and insulin-sensitizing effects reported for SHLP2, SHLP6 has been reported to increase apoptosis in some cell models, suggesting distinct, and potentially opposing, roles within the SHLP family.
▸Limited independent follow-up: SHLP6 has received substantially less subsequent research attention than SHLP2 or Humanin, and its receptor(s) and downstream signaling pathway are not well characterized.

Evidence Summary

Preclinical Only -- Limited DataNaturally occurring mitochondrial-derived peptide; not FDA-approved for any indication. For research and laboratory reference only -- no medical claims.

Evidence StrengthLimited